THC drug interactions · Benzodiazepines · Opioids · Antidepressants · Immunosuppressants · Blood pressure medications · Blood sugar medications. Sometimes, THC can amplify the effect of certain medications. For example, THC can increase the sedative effects of benzodiazepines, since THC sometimes has its own sedative effect. Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels after weight loss.
Delta-9-tetrahydrocannabinol (THC) and cannabidiol are pharmacologically active cannabinoids in marijuana that are metabolized in cytochrome P450 (CYP), 3A4; THC is also metabolized by CYP2C9, a liver enzyme. The Delta-8 is a degraded delta-9, has a lot in common with its older sister compound and is simply a softer version. Effect of repeated administration of 11-hydroxy-delta 8-tetrahydrocannabinol, an active metabolite of delta 8-tetrahydrocannabinol, on the enzymatic system that metabolizes liver microsomal drugs in mice. Be sure to ask your doctor about possible drug interactions in Delta-8 and make sure that you are up to date with current research on THC.
When you start taking Delta-8, keep track of small details, such as how much Delta-8 you took, what time you took the prescription, what time you took your Delta-8 dose, how severe the effects were, or how long they lasted. Delta-8 is known to be much less potent, so it is believed to have an even lower potential for drug interactions. We mentioned earlier that CYP3A4 is a metabolite needed to break down these drugs in the system. One study found that studies on the inhibition and induction of THC, CBD and CBN of the main human isoforms of CYP-450 generally reflect a low risk of clinically significant drug interactions with most uses, but it also noted that human trials are lacking and that more information is needed.
Of course, as with anything, the lower the dose of delta-8 you take while the drug is active in your body, the lower the risk of an interaction. The most important step, of course, is to discuss Delta-8 with your doctor before combining any substances or changing your medication routine. Grapefruit is known to inhibit the CYP3A4 enzyme, which means that it can delay or prevent the absorption of drugs that depend on that enzyme. One of the biggest advantages of Delta-8-THC is that it's federally legal when made with legal hemp material, meaning you can buy it online and have it shipped directly to your door.
Now that delta-8-THC has become the center of attention, it is crucial to understand the risk of drug interactions between delta-8.Obviously, the first thing you should always do is ask your doctor about the possibility of an interaction. This means that they have the potential to react with any drug that uses the same metabolic pathway, which unfortunately is most prescription drugs.